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Possibility Summary Offered data haven't set up an association between metronidazole use during pregnancy and key birth defects, miscarriage or other adverse maternal or fetal results. No fetotoxicity was noticed soon after oral administration of metronidazole in Expecting rats or mice. The obtainable info usually do not allow the calculation of appropriate comparisons concerning the systemic exposures of metronidazole noticed in animal research for the systemic exposures that could be predicted in human beings immediately after topical usage of METROGEL.
METROGEL is often a nitroimidazole; use with care in clients with proof of, or history of, blood dyscrasia.
Oral metronidazole has actually been reported to potenti-ate the anticoagulant influence of coumarin and warfarin causing a prolongation of prothrombin time. The influence of topical metronida-zole on prothrombin time just isn't known.
Neurologic Condition: Peripheral neuropathy, characterized by numbness or paresthesia of an extremity continues to be reported in people treated with systemic metronidazole.
Right away reevaluate METROGEL therapy if irregular neurologic indicators show up. Administer metronidazole with caution to people with central anxious technique ailments.
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